Grimsby's tactics of playing just one man up front did not work and when striker Gary Jones went on after 27 minutes, with the home side already trailing 2-0, it turned the game Grimsby's way.
Some crazy defending which let in strikers Scott McGleish on 22 minutes and Jermaine Easter two minutes later looked to have put play-off hopefuls Wycombe on track for three much needed points.
Grimsby tried to pull things round before the break but to no effect and there were just 19 minutes left when the fight-back started.
Jones wiggled through down the right and, from what looked like an impossible angle, his shot left keeper Ricardo Batista with no chance.
This instantly lifted the crowd, who could have been forgiven for dozing off in the spring sunshine.
Two minutes later striker Danny North raced clear and, with an equaliser looking on the cards, he was denied by a Batista save.
But with an extra man up front striker Peter Bore, having joined the fray, Grimsby were not to be denied. A corner came in from the right and midfielder Paul Bolland swivelled and fired in a terrific volley to make it 2-2.
The goal capped a man-of-the-match performance from Bolland, who admits he does not do tap-ins in front of goal.
With a draw doing little for Wycombe's play-off hopes they stormed forward in the remaining 12-or-so minutes, including added-on time, in which either side could have snatched a winner.
However there was no further scoring, but Grimsby undoubtedly finished the happier of the sides with the point seeming more like three after coming back from the dead. For Wycombe it was two points dropped, but it could have been even worse.